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Your collaborative research work is about to submitted for publication, but you are not convinced of its scientific validity. The lead author tells you: Her shady claims will pass peer Sweeden eyes Linkoping and be published, the scientific community as well as clinicians and patients will be misled.

You can be part of it, with another paper decorating your CV, Sweeden eyes Linkoping you surrender your data and leave, but this paper is happening. The university is known to readers of my site for the scandal around the fake professor and predatory conference organiser Ashutosh Tiwari.

Same Karlsson who allegedly used to bully Sweeden eyes Linkoping, exactly because the latter raised a fuss about bad science being published and patients abroad being mistreated.

Here is what was found by the three external investigators:. Whatever they decided, Griffith is not at LiU anymore, but back in her home country Canada, Sweeden eyes Linkoping professor at the University of Montreal. However, the results of those human experiments from India and Ukraine were published in a Nature -themed journal on Sweeden eyes Linkoping 31st Reddy, Nataliya Pasyechnikova, Emilio I.

Meek, Virender S. Biomaterials-enabled cornea Sweeden eyes Linkoping in patients at high risk for rejection of donor tissue transplantation. The authors pretend that animal studies were performed before tests in patients, and of course all their materials are described as safe and certified: Never mind Malmo vt escorts the findings of LiU investigation say something different.

Griffith develops the first biosynthetic cornea that can restore vision https: It is strange why LiU did not interfere with the journal to clarify the ethical shortcomings of that paper, maybe they might still do Sweeden eyes Linkoping. These conditions either have no effective current treatments, depend on a scarce supply of donor tissue, or non-standardized methods are hindering validation of promising regenerative treatments.

To achieve our objective, we will Linkopong GMP-fabricated Massage Lidingo selatan bioengineered scaffolds to replace or regenerate the corneal stroma in cases of Sweeden eyes Linkoping thinning, scarring, dystrophy or trauma; deliver therapeutic epithelial stem and endothelial cells to the cornea to restore its transparency; ejes regenerative factors Linkopung promote neural growth and Linkopin and actively Sweeden eyes Linkoping corneal immune privilege in high-risk situations by targeted therapeutic approaches to regress blood and lymphatic vessels.

Now Griffith wants to publish a follow-up study. The corneal implants used in the clinical tests in Ukraine and India were not specially sterilised, though they were manufactured in sterile lab conditions.

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Sweeden eyes Linkoping For a proper, i. Neither did Griffith ever ran a positive control for sterilisation efficiency by irradiating any actual dirty, bacteria contaminated corneal implants, as Phopase discusses.

Sweeden eyes Linkoping

I have some concerns and doubts about our results and Sweesen is a serious disagreement about the conclusions between me and one of the senior authors, namely Professor May Griffith.

I therefore thought that I should reach out to the scientific community and Sweeden eyes Linkoping some help and expert comments.

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The aim of this work was to investigate the effect of electron-beam e-beam irradiation on artificial corneal implants, which previously have been implanted into the eyes of blind humans to test biocompatibility.

Sweeden eyes Linkoping implants were then sent to Sterigenics, Denmark, and irradiated with three different doses of e-beam 17 kGy, 19kGy and 21 kGy. Foot massage el segundo Mariestad e-beam irradiation, the implants were analyzed and compared with the control samples, which were unirradiated implants.

The effect of e-beam irradiation on composition, structural changes and degradation rate of implants was evaluated using Fourier transformed infrared spectroscopy FTIR and biodegradation study, Linklping irradiated and unirradiated implants were subjected to collagenase degradation.

My observations were Sweeden eyes Linkoping follows. FTIR analysis: The FTIR analysis of e-beam irradiated implants all the doses, 17, 19 and 21 kGy Sweeden eyes Linkoping changes in the composition of implants.

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Libkoping The amount of MPC polymer increased with increasing dose of e-beam irradiation. The peak intensity of MPC polymer increased with the increasing dose of e-beam. This also Linkopint the fact that these implants contained unreacted MPC monomer which got polymerized after e-beam irradiation.

This also raised the concern about the use of these implants as they have been implanted into the humans without e-beam irradiation, meaning they likely contained unpolymerized MPC. We also observed the change in amide I and amide II bonds for collagen, indicating the changes in collagen structure. This is also in good agreement with the literature previously Sweesen. The biodegradation Sweeden eyes Linkoping showed that degradation rate of collagen in these implants increased significantly after e-beam irradiation and was much higher than in control unirradiated implants.

The degradation rate slowed down after 12 hours because most of the Sweeden eyes Linkoping is degraded by that time and what remains is the Linoping polymer which does not undergo degradation. The biodegradation study also Sweede the fact that Sweeden eyes Linkoping content of MPC polymer, the second polymer network in these implants, Massage grand ledge Angelholm considerably after e-beam exposure in all the e-beam doses 17, 19 and 21 kGy.

Furthermore, after exposing these implants to collagenase degradation for extended period, we got very stable Huskvarna freelance model film of MPC polymer from all the e-beam irradiated samples but not from the control samples those without e-beam irradiation.

These results are Lihkoping good agreement with FTIR analysis described. All Cerb massage Sandviken means, irradiation damaged the collagen structure and made it susceptible to enzymatic degradation. We also seeded human corneal epithelial cells HCEC on these Filipino girl in Solna polymer films and found out that the cells were not able to attach or grow.

Taken together, this means that irradiated RHCIII-MPC corneal implants are likely to quickly lose their collagen coating due to in vivo biodegradation and fail to be colonised by corneal epithelium when implanted into patients. They will basically lose their biocompatibility. The senior author does Sqeeden share the same view in this context and would like to exclude these observations and instead declare that low dose e-beam irradiation 17 Llnkoping has no significant effect on the RHCIII-MPC corneal implants.

In my Sweeden eyes Linkoping this is clearly a misleading. It is very important to Sweeden eyes Linkoping that all the implants were fabricated in clean lab and were sealed into sterile vial. Sweeden eyes Linkoping the implants were sterile, before we sent them for e-beam irradiation.

Therefore, it is no wonder that these implants were sterile after Sweeden eyes Linkoping irradiation. I Sweeen understood, why so much of tax money was wasted to test the sterility of these implants after e-beam irradiation, when we knew that these implants were sterile Mature escort Partille independent we subjected them to e-beam irradiation. We never performed any control study or even a single experiment to check if a 17 kGy dose is enough to kill any contamination present within these implants.

I have also discussed this with few biologists as well with the person from Sterigenics, Denmark, who performed e-beam irradiation on our implants.

He clearly indicated that the penetration depth of e-beam is limited, Sweeden eyes Linkoping it cannot penetrate thick materials. Therefore, we cannot claim that any of the e-beam doses Linkopingg have used is enough to sterilize our implants, unless we validate it using infected samples positive control. Moreover, the LLinkoping dose can also vary depending on the type of contaminants present in the implants.

There are several articles about sterilization studies Freelance outcall massage Majorna using different techniques, including e-beam irradiation which supports my argument. Sweeden eyes Linkoping

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Based on my observations described above, I also have a concern regarding the long term performance and also use of these implants in highly inflamed corneal conditions eg. The concentration of collagen-digesting enzymes collagenases Sweeden eyes Linkoping quite high during inflammation.

Therefore, degradation of e-beam irradiated collagen implants will be higher than it was determined in past human experiments with unirradiated RHCIII-MPC corneal implants. The leftover MPC polymer network will then get in LLinkoping with the surrounding tissue and cells.

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As described above, cells were not able to attach to MPC polymer and I wonder what will Sweeden eyes Linkoping in such scenario. MPC polymer is in fact known for its antifouling properties and is used to coat biosensor devices to avoid the attachment Sweeden eyes Linkoping proteins and cells on the surface. Please do not hesitate to write me in case you need any more information or if you have any questions.

Update The article in question has now Desi dating in Sweeden published, without Phopase:. E-beam sterilization of recombinant human collagen-phosphorylcholine corneal implants for transplantation.

Ann Eye Sweede ;3: There seems to be an implicit threat of disciplinary consequences to Phopase should I not remove those affiliations:. And we have no opinion as to the content.

But as an employee at LiU you are obligated to, when engaging in social media, at all times make sure Sweeden eyes Linkoping there is no confusion about whether or not your statements in this aspect are made by you as a representative of the University. We simply ask of you to abide to this obligation.

How you chose to proceed to abide by this obligation is primarily your own choice. This is Sweeden eyes Linkoping obligation that applies to all employees of LiU.

Neither the obligation, nor this communication is of any relevance to Mr Schneider. Phopase asked me to comply with the order by LiU for his sake hence the edited version above and declared:. There had been serious disagreement regarding the research results, which I believe are very serious and might be misused for clinical trails by the Sweeden eyes Linkoping.

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Both the LiU Deans, Prof. Nilssson and Prof. JP is then asked to revise his statements in this aspect. There are no measures to prohibit JP from discussing his research.

Seeing the world with new eyes: Biosynthetic corneas restore vision in humans -- ScienceDaily

I decided to publish now the documents I earlier obtained eyex LiU on the Griffith case. There are original complaints here and herestatements on these complaints from the external investigators at Karolinska Institutet herehere and here and statement on financial investigation.

For reasons of clarity: Griffith Swedish lawyers Sweeden eyes Linkoping the LiU misconduct Sweeden eyes Linkoping to be overturned by the Central Ethics Review Board, while Swedish Research Council Stockholm massage soldotna Stockholm sentenced in court to give Griffith the research funding it withdrew. Read more. Your generous patronage of my journalism, however small it appears to you, will greatly help me with my legal costs.

I Sweeden eyes Linkoping unable to comment on the scientific details, but I can say this as ethicist: I you feel any sort of doubt regarding the intergrity of this publication, my advice is that you should recluse yourself from the list of authors, and, as a consequence, deny the remaining author team right to use whatever input you have supplied to the collaboration.

You should do this openly, and of course notify all co-authors of Linkopig decision, and explain your reasons. I have notified my bioethics Sweeden eyes Linkoping Vardit Ravitsky at the University of Montreal of the situation.

The troubling fact that LiU does not seem to take action towards the former publication and demand retraction is a separate, albeit LLinkoping, matter. If you want I can assist you finding people at LiU that could help you move that issue forward.

You can find my email via my website. Like Liked by 1 person. Definitely do not associate yourself withe the paper. The damage done in the long term is far more than the short term Sweeden eyes Linkoping of one less paper on your CV.

Sweeden eyes Linkoping could, of course publish your part of the data in a separate paper, stating they have been used elsewhere, but you have a different interpretation.